Investigation and Characterization of the Jumping Translocation Breakpoint (JTB) Protein using Mass Spectrometry based Proteomics
نویسندگان
چکیده
منابع مشابه
mass spectrometry-based proteomics in the life sciences: a review
proteomics concerns itself with the characterization and function of all cellular proteins, the ultimate determinants of cellular function. mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have...
متن کاملComputational Mass Spectrometry–Based Proteomics
Proteomics is defined as the system-wide characterization of all the proteins in an organism in terms of their sequence, localization, abundance, post-translational modifications, and biomolecular interactions. Modern proteomic investigations are increasingly quantitative and comprehensive [1]. Examples include the relative quantification of over 4,000 proteins in haploid and diploid yeast, whi...
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The amplification of cellular proto-oncogenes, a common feature of malignant tumors, results in distinct cytogenetic alterations in carcinomas and hematopoietic neoplasms. In carcinomas, it mainly produces elongation of chromosomes by homogeneously staining regions or extrachromosomal elements referred to as double minutes. In hematopoietic malignancies, in which homogeneously staining regions ...
متن کاملJumping translocation breakpoint regions lead to amplification of rearranged Myc.
The amplification of cellular proto-oncogenes, a common feature of malignant tumors, results in distinct cytogenetic alterations in carcinomas and hematopoietic neoplasms. In carcinomas, it mainly produces elongation of chromosomes by homogeneously staining regions or extrachromosomal elements referred to as double minutes. In hematopoietic malignancies, in which homogeneously staining regions ...
متن کاملJumping Translocation Breakpoint Regions Lead to Amplification of Rearranged Myc
The amplification of cellular proto-oncogenes, a common feature of malignant tumors, results in distinct cytogenetic alterations in carcinomas and hematopoietic neoplasms. In carcinomas, it mainly produces elongation of chromosomes by homogeneously staining regions or extrachromosomal elements referred to as double minutes. In hematopoietic malignancies, in which homogeneously staining regions ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.05077